费腾，博士，教授，博士生导师。现就职于必赢272net入口生物技术研究所。国家级海外高层次人才计划青年项目入选者，辽宁省“兴辽英才计划”青年拔尖人才。目前主要运用多种高通量的功能基因组学结合精细的分子细胞学研究手段，探讨基因编辑技术与基因治疗、肿瘤等复杂疾病分子机理、药物靶标挖掘及疾病诊疗策略开发等领域的关键科学问题。近年来在Nature Biomedical Engineering、Cell Stem Cell、Cell Research、Nature Structural & Molecular Biology、Nature Communications、PNAS和Genome Biology等国际权威学术期刊发表论文五十余篇。主持多项国家及省部级科研项目。担任第八届教育部科技委员会委员、中国细胞生物学学会理事等。
教育和工作经历
2016-至今必赢272net入口，教授
2011-2016 哈佛大学医学院/Dana-Farber癌症研究所，博士后
2005-2010 清华大学，生物学，博士
2001-2005 必赢272net入口，生物工程，学士
主要科研方向
1. 基因编辑技术及基因治疗
2. 肿瘤等复杂疾病的分子机理
3. 药物靶点挖掘及疾病诊疗技术开发
主持的基金项目
1. 国家自然科学基金面上项目，2025.01-2028.12，主持
2. 广东省基础与应用研究基金委员会粤佛联合基金项目，2023.11-2026.10，主持
3. 辽宁省科技厅重点研发项目，2022-2023，主持
4. 国家自然科学基金面上项目，2021.01-2024.12，主持
5. 辽宁省组织部“兴辽英才计划”青年拔尖人才项目，2019-2021，主持
6. 国家自然科学基金面上项目，2019.01-2022.12，主持
7. 国家级青年人才项目，2016-2019，主持
代表性论文
(#) 第一作者; (*) 通讯作者
1. Shan H, Fan S, Li Q, Liang R, Chen Z, Wang S, Wang X, Li Y, Chen S, Yu K, Fei T*.Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis. Genome Biol. 2025 Mar 17;26(1):59. doi: 10.1186/s13059-025-03531-8.
2. Tian Y#, Ma R#, Zhao W#, Wang S, Zhou C, Wu W, Yang B, Xin H, Wang H, Li P, Li R, Liu C, Lu Y, Yu Q, Song C, Zhang H, Liang R, Zhang L, Zhou D, Zhao X, Wu Z, Qi Y, Wang R, Fei T*, Yang X*. Comprehensive characterization of early-onset lung cancer, in Chinese young adults. Nat Commun. 2025 Feb 26;16(1):1976. doi: 10.1038/s41467-025-57309-4.
3. Zhong C#, Jiang WJ#, Yao Y, Li Z, Li Y, Wang S, Wang X, Zhu W, Wu S, Wang J, Fan S, Ma S, Liu Y, Zhang H, Zhao W, Zhao L, Feng Y, Li Z, Guo R, Yu L, Pei F, Hu J, Feng X, Yang Z, Yang Z, Yang X, Hou Y, Zhang D, Xu D, Sheng R, Li Y, Liu L, Wu HJ*, Huang J*, Fei T*.CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.Nat Commun. 2024 Jun 29;15(1):5502. doi: 10.1038/s41467-024-49673-4.
4. Li Z#, Li Z#, Cheng X#, Wang S, Wang X, Ma S, Lu Z, Zhang H, Zhao W, Chen Z, Yao Y, Zhang C, Chao L, Li W*, Fei T*. Intrinsic targeting of host RNA by Cas13 constrains its utility. Nat Biomed Eng.2024 Feb;8(2):177-192. doi: 10.1038/s41551-023-01109-y. Epub 2023 Oct 23.
5. Cheng X#, Li Z#, Shan R, Li Z, Wang S, Zhao W, Zhang H, Chao L, Peng J, Fei T*, Li W*. Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches. Nat Commun. 2023 Feb 10;14(1):752. doi: 10.1038/s41467-023-36316-3.
6. Li Z#, Zhao W#, Ma S#, Li Z, Yao Y, Fei T*. A chemical-enhanced system for CRISPR-Based nucleic acid detection. Biosens Bioelectron. 2021 Jul 9;192:113493. doi: 10.1016/j.bios.2021.113493.
7. Li Z*, Yao Y, Cheng X, Li W, Fei T*. An in silico drug repositioning workflow for host-based antivirals. STAR Protoc. 2021 Jul 7;2(3):100653. doi: 10.1016/j.xpro.2021.100653.
8. Li Z#, Yao Y#, Cheng X#, Chen Q, Zhao W, Ma S, Li Z, Zhou H, Li W*, Fei T*. A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA viruses. iScience. 2021 Feb 5;24(3):102148. doi: 10.1016/j.isci.2021.102148.
9. Fei T#, Li W#, Peng J#, Xiao T, Chen CH, Wu A, Huang J, Zang C, Liu XS*, Brown M*. Deciphering essential cistromes using genome-wide CRISPR screens. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25186-25195. doi: 10.1073/pnas.1908155116
10. Fei T#*, Chen Y#, Xiao T, Li W, Cato L, Zhang P, Cotter MB, Bowden M, Lis RT, Zhang SG, Wu Q, Feng FY, Loda M, He HH, Liu XS*, Brown M*. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5207-E5215. doi: 10.1073/pnas.1617467114
11. Du Z#, Fei T#, Verhaak RG, Su Z, Zhang Y, Brown M*, Chen Y#*, Liu XS*. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 2013 Jul;20(7):908-13. doi: 10.1038/nsmb.2591
12. Zhang J#, Fei T#, Li Z#, Zhu G, Wang L, Chen YG*. BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells. J Biol Chem. 2013 Mar 22;288(12):8053-60. doi: 10.1074/jbc.M112.433995
13. Li Z#, Fei T#, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG*. BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell. 2012 Feb 3;10(2):171-82. doi: 10.1016/j.stem.2011.12.016
14. Sun Y#, Fei T#, Yang T#, Zhang F, Chen YG, Li H, Xu Z*. The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 2010 Dec 10; 285(50):39039-50. doi: 10.1074/jbc.M110.168351
15. Fei T, Zhu S, Xia K, Zhang J, Li Z, Han JD*, Chen YG*. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res. 2010 Dec; 20(12):1306-18. doi: 10.1038/cr.2010.158
16. Fei T#, Xia K#, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Xiao H, Han J*, Chen YG*. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res. 2010 Jan; 20(1):36-44. doi: 10.1101/gr.092114.109
联系方式
地址：辽宁省沈阳市浑南区195号，必赢272net入口浑南校区生命学馆
E-mail：feiteng@mail.neu.edu.cn
邮编：110169