盛韧，博士，教授，博士生导师，独立PI，课题组组长。现就职于必赢272net入口。
教育和工作经历
2004.09-2008.07吉林大学化学学院，理学学士
2008.08-2013.12伊利诺伊大学化学学院，理学博士
2014.01-2015.04 伊利诺伊大学化学学院，博士后研究员
2015.05-2018.07 哈佛大学医学院/波士顿儿童医院，博士后研究员
2018.08至今必赢272net入口，“海外百人”特聘教授
2025.01至今广州医科大学基础医学院，特聘客座教授
主要科研方向
1. 细胞信号传导
2. 肿瘤靶向治疗
3. 肿瘤免疫微环境与空间转录
主持的基金项目
1. 国家自然科学基金面上项目31970721，2020.01-2023.12，主持。
2. 国家自然科学基金面上项目32470761，2025.01-2028.12，主持。
3. 国家自然科学基金青年项目（C类）81902830，2020.01-2022.12，主持。
4. 国家自然科学基金-国际(地区)合作与交流项目C-0030，2020.10-2022.9，子课题负责人。
5. 教育部中央高校自然科学专项资金资助N161003001，2018.08-2018.12，主持。
6. 教育部中央高校自然科学专项资金资助N182005006，2019.01-2020.12，主持。
7. 辽宁省组织部兴辽英才计划“青年拔尖人才”项目XLYC1807239，2019.01-2021.12，主持。
8. 辽宁省自然科学基金联合基金2023-MSBA-066，2023.12-2025.12，主持。
9. 必赢272net入口“海外百人”特聘教授研究资助，2018.08-2023.08，主持。
代表性论文（按时间倒序）（#第一作者/*通讯作者）
1. Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis. Ma L#, Pang Z#, Zhang H, Yang X, Zheng S, Ding W, Han Q, Zhang X, Cao L, Fei T, Wang Q, Gao D, He A*, Hu K-B*, Li X*, Sheng R*. Proceedings of the National Academy of Sciences, USA 2025 Feb 12, 122 (7) e2415244122.
2. Deciphering Immune Predictors of Immunotherapy Response: A Multiomics Approach at the Pan-Cancer Level. Li X*, Pan L, Li W, Xiao C, Chew V, Zhang X, Li D, Wang Z, Kosar M, Zhu J, Long W, Ding P, Ginhoux F, Loscalzo J, Buggert M, Zhang X, Sheng R*, Wang Z*. Cell Reports Medicine, 2024 Dec 16. In press.
3. STING agonists and PI3Kγ inhibitor co-loaded ferric ion-punicalagin networks for comprehensive cancer therapy. Zheng S#, Guo Y#, Han Q#, Peng X, Sheng R*, Liu S*, Li Z*. International Journal of Biological Macromolecules, 2024 Oct 23:136776.
4. HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via non-canonical phosphorylation. Pang Z, Zhang H, Zheng S, Liu C, Han Q, Chen Y, Li Z, Zhang X, Cao L, Qiang W, Cao Y, Sun X, Zhao P*, Li X*, Zheng Q*, Sheng R*. Hepatology, 2024 Nov 13. Online ahead of print.
5. CDKL3 is a targetable regulator of cell cycle progression in cancers. Zhang H#, Lin J#, Zheng S, Ma L, Pang Z, Yin H, Meng C, Wang Y, Han Q, Zhang X, Li Z, Cao L, Liu L, Fei T, Gao D, Yang L, Peng X, Ding C*, Wang S*, Sheng R*. Journal of Clinical Investigation. 2024 Jul 4;134(16):e178428.
6. Anti-pan-Rspo Chimeric Protein-Conjugated Albumin Nanoparticle Provides Promising Opportunities in Cancer Targeted Therapy. Zheng S#, Zhang X#, Pang Z, Liu J, Liu S*, Sheng R*. Advanced Healthcare Materials, 2023 Jul 6;e2301441.
7. USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential. Wang Y#, Mao A#, Liu J#, Li P#, Zheng S, Tong T, Li Z, Zhang H, Ma L, Lin J, Pang Z, Han Q, Qi F, Zhang X, Chen M, He X, Zhang X, Fei T, Liu B, Gao D, Cao L*, Wang Q*, Li Y*, Sheng R*. Cell Chemical Biology, 2023 Aug 11;S2451-9456(23)00246-5.
8. Aberrant cholesterol metabolism and Wnt/β-catenin signaling coalesce via Frizzled5 in supporting cancer growth. Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X, Zhao C, Qi J, Cao L, Wang M*, He X*, Sheng R*. Advanced Science, 2022 Oct;9(28):e2200750.
9. Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol. Liu SL#, Sheng R#, Jung JH, Wang L, Stec E, O’Connor MJ, Song S, Bikkavilli RK, Winn R, Lee D, Baek K, Ueda K, Levitan I, Kim KP, Cho W*. Nature Chemical Biology, 2017 Mar;13(3):268-274.
10. Lipids regulate Lck activity through their interactions with the Lck SH2 domain. Sheng R#, Jung DJ#, Silkov A, Kim H, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Honig B, Beak K, Ryu S, Lorieau J, Kim YM*, Cho W*. Journal of Biological Chemistry, 2016 Aug 19;291(34):17639:50.
11. SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins. Park MJ#, Sheng R#, Silkov A#, Jung DJ, Wang ZG, Xin Y, Kim H, Thiagarajan-Rosenkranz P, Song S, Yoon Y, Nam W, Kim I, Kim E, Lee DG, Chen Y, Singaram I, Wang L, Jang MH, Hwang CS, Honig B, Ryu S, Lorieau J*, Kim YM*, Cho W*. Molecular Cell, 2016 Apr 7; 62(1): 7-20.
12. Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling. Sheng R#, Kim H#, Lee H#, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK*, Cho W*. Nature Communications, 2014; 5:4393.
13. Cholesterol modulates cell signaling and protein networking by specifically interacting with scaffold proteins. Sheng R#, Chen Y#, Yung Gee H, Stec E, Melowic HR, Blatner NR, Tun MP, Kim Y, Källberg M, Fujiwara TK, Hye Hong J, Pyo Kim K, Lu H, Kusumi A, Goo Lee M*, Cho W*. Nature Communications, 2012;3:1249.
14. Genome-wide identification and functional annotation of dual specificity protein- and lipid-binding modules that modulate protein interactions at the membrane. Chen Y#, Sheng R#, Kallberg M#, R. Silkov A, Tun MP, Bhardwaj N, Kurilova S, Hall RA, Honig B*, Lu H*, and Cho W*. Molecular Cell, 2012 Apr 27;46(2):226-37.
联系方式
地址：辽宁省沈阳市浑南区创新路195号
邮编：110169
E-mail：shengren@mail.neu.edu.cn/shengren1211@126.com