汪冰，博士，特聘教授（二级），博士生导师。现就职于必赢272net入口生化与分子生物学研究所。曾获国务院特贴专家，辽宁省特聘教授领军人才，辽宁省高端引进人才百人等称号。现任辽宁省细胞生物学会副理事长，辽宁省免疫学会常务理事，中国生化与分子生物学会教育委员会常务理事。被选为国家科学进步奖、长江学者、青年长江 等评审专家。2013年组建生化与分子生物学研究所，为必赢272net入口打造了与国际接轨的平台和团队。承担了“生物化学”、“生物技术制药”和“细胞分离技术”等课程。
教育和工作经历
1982.07-1986.07 中国药科大学生化制药专业，理学学士
1986.07-1988.07 吉林大学生化专业，助教
1988.07-1991.07 吉林大学生化专业，理学硕士
1991.07-1993.09 吉林大学免疫教研室讲师，博士研究生
1993.07-1999.03 日本九州大学免疫学，免疫博士学位，同年获得吉林大学医学博士学位。
1999.03-2004.10 加拿大麦吉尔大学，生化系，博士后
2004.10-2012.12 加拿大麦吉尔大学，生化系，研究员
2012.12-至今 必赢272net入口，生命与健康学院，教授
主要科研方向
1. B细胞受体相关蛋白31（BAP31）蛋白的功能解析
首次实施了膜蛋白酵母双杂交：半分泛素膜蛋白酵母双杂交的文库构建和筛选；明确了BAP31的本质之一是内质网相关降解（ERAD）通路的蛋白；建立了BAP31首个动物模型：BAP31条件缺陷鼠，发现了多种BAP31的新功能；筛选了干扰BAP31功能的胞内抗体潜在抗肿瘤新药，并申请了专利。
2. 蛋白酪氨酸磷酸酶（PTP）PEP亚家族PTPN22（PTPPEP）和PTPN18（PTP-SHCF）蛋白的功能解析
建立了首个PTPPEP酶活性缺陷型转基因鼠和条件转基因鼠动物模型。解析了PTPN18和PTPN22在免疫系统和肿瘤的发生发展中的多种功能。
主持的基金项目
1. 国家自然科学基金面上项目：BAP31在小鼠中的功能解析（31370784），88万，主持。
2. 国家自然科学基金面上项目：蛋白酪氨酸磷酸酶PTP-PEP调节T细胞受体表达及相应机理研究（31670770），81万，主持。
3. 兴辽特聘教授：BAP31参与肿瘤免疫疾病的相关调控机制及应用研究（XLYC1902063），100万，主持。
4. 国家科委重大专项：解析肿瘤微环境外泌体蛋白对肿瘤内在驱动途径的影响机制（2016YFC1302402），30万元，子项目主持。
5. 辽宁省重点研发：新型癌症相关蛋白BAP31信号通路调控机制研究及其胞内抗体新药筛选与开发（2020JH2/10300080），30万元，支持。
6. 教育部领军人才启动基金：蛋白质功能解析（02150021233058），650万元，主持。
代表性论文
1. Yu Y, Ba X, Li T, Xu W, Zhao J, Zhang N, Zhao Y, Wang T, Zhang X, Wang X, Bai B, Wang B. PTPN22 and the pathogenesis of ulcerative colitis: Insights into T cell differentiation and the JAK/STAT signaling pathway. Cell Signal. 2024 Dec 4:111551. doi: 10.1016/j.cellsig.2024.111551
2. Jiang X, Zhu B, Li G, Cui S, Yang J, Jiang R, Wang B.p20BAP31 promotes cell apoptosis via interaction with GRP78 and activating the PERK pathway in colorectal cancer. International Journal of Biological Macromolecules. 2024, June; 272(2); 132870
3. Jiang X, Li G, Zhu B, Yang J, Cui S, Jiang R, Wang B.p20BAP31 Induces Autophagy in Colorectal Cancer Cells by Promoting PERK-Mediated ER Stress.Int J Mol Sci. 2024 May 7;25(10):5101. doi: 10.3390/ijms25105101
4. Zhao B, An F, Hao Z, Zhang W, Wang B.BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling.Int J Mol Sci. 2024 May 2;25(9):4962. doi: 10.3390/ijms25094962.
5. Namusamba M, Wu Y, Yang J, Zhang Q, Wang C, Wang T, Wang B.BAP31 Promotes Angiogenesis via Galectin-3 Upregulation in Neuroblastoma.Int J Mol Sci. 2024 Mar 3;25(5):2946.
6. Qi Zhang, Changli Wang, Yufei Wu, Jingjing Liu, Tianyi Wang, Bing Wang BAP31-Mediated miR-206/133b Cluster Promotes TransendothelialMigration and Metastasis of Colorectal Cancer. Int. J. Mol. Sci. 2023, 24, 16740. https://doi.org/10.3390/ijms242316740
7. Bai B, Li T, Zhao J, Zhao Y, Zhang X, Wang T, Zhang N, Wang X, Ba X, Xu J, Yu Y, Wang B.The Tyrosine Phosphatase Activity of PTPN22 Is Involved in T Cell Development via the Regulation of TCR Expression.Int J Mol Sci. 2023 Sep 25;24(19):14505. doi: 10.3390/ijms241914505.
8. Bai B, Wang T, Zhang X, Ba X, Zhang N, Zhao Y, Wang X, Yu Y, Wang B.PTPN22 activates the PI3K pathway via 14-3-3τ in T cells.FEBS J. 2023 Sep;290(18):4562-4576.
9. Wang T, Wang C, Wang J, Wang B.An Intrabody against B-Cell Receptor-Associated Protein 31 (BAP31) Suppresses the Glycosylation of the Epithelial Cell-Adhesion Molecule (EpCAM) via Affecting the Formation of the Sec61-Translocon-Associated Protein (TRAP) Complex.Int J Mol Sci. 2023 Sep 30;24(19):14787.
10. Liu J, Zhang Q, Wang C, Yang J, Yang S, Wang T, Wang B.Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/β-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer.Int J Mol Sci. 2023 Sep 21;24(18):14402. doi: 10.3390/ijms241814402
11. Zhao B, Sun L, Yuan Q, Hao Z, An F, Zhang W, Zhu X, Wang B.BAP31 Knockout in Macrophages Affects CD4+T Cell Activation through Upregulation of MHC Class II Molecule.Int J Mol Sci. 2023 Aug 30;24(17):13476. doi: 10.3390/ijms241713476.
12. Liu J, Zhang Q, Wang C, Yang J, Yang S, Wang T, Wang B.Knockdown of BAP31 Overcomes Hepatocellular Carcinoma Doxorubicin Resistance through Downregulation of Survivin.Int J Mol Sci. 2023 Apr 21;24(8):7622. doi: 10.3390/ijms24087622
13. Jiang X, Li G, Zhu B, Zang J, Lan T, Jiang R, Wang B.p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer.Cell Mol Biol Lett. 2023 Mar 28;28(1):25. doi: 10.1186/s11658-023-00434-z.
14. Zhang Q, Wang C, Li R, Liu J, Wang J, Wang T, Wang B.The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation.Front Oncol. 2023 Feb 21;13:1056903. doi: 10.3389/fonc.2023.
15. Li G, Jiang X, Liang X, Hou Y, Zang J, Zhu B, Jia C, Niu K, Liu X, Xu X, Jiang R, Wang B.BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-κB pathway in acute lung injury mice model.Life Sci. 2023 Jan 15;313:121310. doi: 10.1016/j.lfs.2022.121310. Epub 2022 Dec 20.
16. Wang T, Ba X, Zhang X, Zhang N, Wang G, Bai B, Li T, Zhao J, Zhao Y, Yu Y, Wang B.Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer. Front Immunol. 2022 Oct 20;13:976996.
17. Guo-xun Li, Xiao-han Jiang, Jing-nan Zang, Ben-zhi Zhu, Cong-cong Jia, Kunwei Niu, Xia Liu, Rui Jiang, Bing Wang.B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11bCD18 and PSGL-1 in neutrophils to ameliorate acute lung injury. Int J Biochem Cell Biol. 2022 Sep 19;152:106299.
18. Tao Wang, Xinlei Ba, Xiaonan Zhang, Na Zhang, Guowen Wang, Bin Bai, Tong Li, Jiahui Zhao, Yanjiao Zhao, Yang Yu, Bing Wang. Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2. Cell death & disease. 2022 Aug 18;13(8):720.
19. Qing Yuan, Bo Zhao, Yu-hua Cao, Jia-cheng Yan, Li-jun Sun, Xia Liu, Yang Xu, Xiao-yu Wang, Bing Wang.BAP31 regulates macrophages polarization and wound healing function via Egr-2/ C/EBPb and IL-4Ra/ C/EBPb pathways.J Immunol. 2022 Sep 15;209(6):1059-1070.
20. Qing Yuan, Kunwei Niu, Lijun Sun, Bo Zhao, Xiaoyu Wang, Bing Wang. BAP31 affects macrophage polarization through regulating helper T cells activation. J Mol Histol. 2022 Oct;53(5):843-855. doi: 10.1007/s10735-022-10095-5.
21. Tianye Li, Zhenzhen Hao, Zihan Tang, Chunting Li, Linglin Cheng, Tao Wang, Xiaojin Zhu, Yunhao He, Yongye Huang, Bing Wang. BAP31 Regulates Wnt Signaling to Modulate Cell Migration in Lung Cancer. Frontiers in oncology, DOI: 10.3389/fphar.2021.804615. PMID: 35153759
22. Huang Y, Zhou Z, Zhang J, Hao Z, He Y, Wu Z, Song Y, Yuan K, Zheng S, Zhao Q, Li T,Wang B. lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell.J Cell Mol Med. 2021 Jun 24. doi: 10.1111/jcmm.16742.
23. Namusamba M, Li Z, Zhang Q, Wang C, Wang T, Wang B. Biological roles of the B cell receptor-associated protein 31: Functional Implication in Cancer.Mol Biol Rep. 2021 Jan;48(1):773-786. doi: 10.1007/s11033-020-06123-w. Epub 2021 Jan 13
24. Xia Liu, Qing Yuan, Guo-xun Li, Cong-cong Jia, Jingyu-Liu, Ji-kai Xu, Xiao-yu Wang, Yue Hou, Bing Wang*. Regulation of oxygen species by BAP31 through its effect on p22phox and keap1/Nrf2/HO-1 signaling pathway in microglia. Oxidative Oxid Med Cell Longev. 2021 Mar 9;2021:1457089. doi: 10.1155/2021/1457089.
25. Tianye Li, Yang Yu, Hang Shi, Yuhua Cao, Xiangfu Liu, Zhenzhen Hao, Yuping Ren, Gaowu Qin, Yongye Huang, Bing Wang. Magnesium in combinatorial with valproic acid suppressed the proliferation and migration of human bladder cancer cells. Frontiers in Oncology. 2020Dec 11;10:589112.
26. ZhangX, Wang X, WangT, Bai B, Zhang N, Zhao Y, Yu Y, Wang B. Efficient delivery of triptolide plus miR-30-5p inhibitor by use of modified MSNs has therapeutic efficacy in rheumatoid arthritis. Frontiers in Bioengineering and Biotechnology. 2020;
27. JiaC, LiG, JiangR, LiuX, YuanQ, LeW, HouY, Wang B. B-cell receptor associated protein31 negatively regulates the expression of monoamine oxidase A via R1. Frontiers in molecular biosciences. 2020 Apr 30;7:64.
28. Xiaonan Zhang, Yang Yu, Bin Bai, Tao Wang, Jiahui Zhao, Na Zhang, Yanjiao zhao, Xipeng Wang, Bing Wang*. PTPN22 interacts with EB1 to regulate T cell 1 receptor signaling. FASEB J. 2020 Jul;34(7):8959-8974.
29. Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B.BAP31regulates IRAK1-dependent neuroinflammation in microglia.J Neuroinflammation. 2019 Dec 28;16(1):281.
30. Wang T，Chen J，Hou Y，Yu Y，Wang B. BAP31 deficiency contributes to the formation of amyloid-βplaques in Alzheimer’s disease by reducing the stability of RTN3. FASEB J. 2019 Apr;33(4):4936-4946.
31. Chen J, Guo H, Jiang H, Namusamba M, Wang C, Lan T, Wang T, Wang B. A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation. International journal of cancer. 2019 Apr 15;144(8):2051-2062.
32. Jia CC, Du J, Liu X, Jiang R, Huang Y, Wang T, Hou Y, Wang B. B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2. Cell Physiol Biochem. 2018;51(4):1799-1814.
33. Jialin Xu, Liya Li, Yanqing Wang, Mu shan, Yaqi Li, Shizhuo Sun, Kunwei Niu,Yang Yu, Bing Wang*. Hepatocyte-Specific Deletion of BAP31 Promotes SREBP1C Activation and Aggravates Liver Steatosis and Insulin Resistance in Mice. The Journal of Lipid Research. 2018 Jan;59(1):35-47.
34. Hou Y, Li G, Wang J, Pan Y, Jiao K, Du J, Chen R, Wang B*, Li N. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705. doi: 10.1038/srep45705.IF4.996
35. Niu K, Xu J, Cao Y, Hou Y, Shan M, Wang Y, Xu Y, Sun M, Wang B*. BAP31 is involved in T cell activation through TCR signal pathways. Sci Rep. 2017 Mar 23;7:44809. doi: 10.1038/srep44809.
36. Huang Y, Yuan L, Li T, Liu X, Yu Y, Ouyang H, Wang B*. IWP2 impairs the development of porcine somatic cell nuclear transfer embryos via Wnt signaling pathway inactivation. Biomed Rep. 2017 Jul;7(1):36-40.
37. Hou Y, Xie G, Liu X, Li G, Jia C, Xu J, Wang B*. Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice. Psychopharmacology. 2016，233（5）：905-916.
38. Huang Y, Yuan L, Li T, Wang A, Li Z, Pang D, Wang B*, Ouyang H. Valproic Acid Improves Porcine Parthenogenetic Embryo Development Through Transient Remodeling of Histone Modifiers. Cell Physiol Biochem. 2015;37(4):1463-73.Doi:10.1159/000438515. Epub 2015 Oct 29.
39. Huang Y, Li Z, Wang A, Han X, Song Y, Yuan L, Li T, Wang B*, Lai L, Ouyang H, Pang D. Chimerism in piglets developed from aggregated cloned embryos. FEBS Open Bio. 2016 Mar 15;6(4):285-302.
40. Yue Hou，Ning Li，Guanbo Xie，Jian Wang，Qing Yuan，Congcong Jia，Xia Liu，Guoxun Li，Yingzhan Tang，Bing Wang*. Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways. Journal of Functional Foods. 2015; 19:676-687.
41. Wang T, Jiang H, Wan L, Zhao Q, Jiang T, Wang B*, Wang S. Potential application of functional porous TiO2 nanoparticles in light-controlled drug release and targeted drug delivery. Acta Biomater. 2015 Feb;13:354-63.
42. Wang T, Zhao P, Zhao Q, Wang B*, Wang S. The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier. Drug Deliv. 2016，23（2）：420-428.
43. Wang B., Nguyen M, Chang N.C, Shore G.C. Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum. EMBO J. 2011, 2;30 (3): 451-2
44. Wang B., Heath-Engel H., Zhang D., Nguyen N, Thomas D.Y., Hanrahan J.W. and Shore G.C. BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell 2008,133(6), 1080-92.
45. Wang, B., Pelletier, J., Massaad, M.J., and Shore, G.C. Yeast Split-ubiquitin Membrane Protein Two-hybrid Screen Identifies BAP31 as a Regulator of the Turnover of Endoplasmic Reticulum-asssociated Protein Tyrosine Phosphatase-like B Mol. Cell. Biol. Apr;24(7): 2767-78. (2004).
46. Wang, B., Nguyen, M. and Shore, G.C. Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. J Biol Chem. 278, 14461-14468, (2003).
47. Wang B., Lemay S., Tsai S. and Veillette A. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol. Cell. Biol. 21, 1077-1088, (2001).
48. Wang B，Kishihara K.，Zhang DL.，Nomoto K，Transcriptional regulationof areceptor protein tyrosine phosphatase gene hPTP-J by PKC-mediatedsignalling pathways in Jurkat Molt-4 lymphoma cells.，Biochimica et Biophysica Acta，1999 1450：331-340.
49. Wang B，Kishihara K，Zhang DL，Hara H，Nomoto K， Molecular cloning andcharacterization of a novel human receptor protein tyrosine phosphatase gene,hPTP-J down-regulation of the gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells.，Biochem. Biophys. Res. Commun.，1997，231：77-81.
联系方式
地址：辽宁省沈阳市浑南区创新路195号
邮编：110169
电话：024-83656125
E-mail：wangbing@mail.neu.edu.cn