赵蒲，女，博士，副教授，博士生导师；现就职于必赢272net入口神经科学研究所；兼任中国抗癌协会肿瘤分子医学专业委员会第二届委员会委员、细胞生物学会细胞工程与转基因生物分会第五届委员会委员；近年来在Journal of pineal research、Hepatology、Cell death & disease、Genes & development、Oncogene、Briefings in bioinformatics、iScience等国际权威学术期刊发表论文30余篇，授权发明专利1项；主持国家省部级科研课题7项，参与国家省部级科研课题4项；获批国家发明专利一项；主讲本科生《细胞生物》、《生理学》，研究生《细胞培养技术》课程； 获“必赢272net入口级优秀班导师”，“本科生优秀毕业论文指导教师”等荣誉称号；指导博士硕士研究生22人，指导学生获“必赢272net入口优秀博士毕业论文”1人次，“必赢272net入口优秀硕士毕业论文”1人次，“必赢272net入口优秀本科生毕业论文”2人次，“辽宁省优秀毕业生”1人次；指导本科生获辽宁省创新创业大赛一等奖，全国生命科学竞赛三等奖等。
教育和工作经历
1999-09 至2004-07, 兰州大学医学院, 预防医学系, 学士
2004-09 至2007-07, 中国人民解放军第四军医大学, 细胞生物学, 硕士
2007-09 至2010-07, 中国人民解放军第四军医大学, 细胞生物学, 博士
2010-10 至2012-10, 美国西北大学，博士后
2017-12 至2019-01, 贝勒医学院,乳腺癌研究中心,访问学者
2013-02 至今, 必赢272net入口, 必赢272net入口, 副教授
主要科研方向
1. 肝癌细胞侵袭和转移的分子机制研究
2. 神经退行性疾病发病机制研究
主持的基金项目
参与的基金项目
代表性论文
第一作者及通讯作者论文：#共同第一作者，*通讯作者
1. Wang, Z., Zhang, Y.H., Zhang, W., Gao, H.L., Zhong, M.L., Huang, T.T., Guo, R.F., Liu, N.N., Li, D.D., Li, Y., Wang, Z.Y.* and Zhao, P.* Copper chelators promote nonamyloidogenic processing of AbetaPP via MT1/2 /CREB-dependent signaling pathways in AbetaPP/PS1 transgenic mice. Journal of Pineal Research, 65 (2018) e12502.
2. Pang, Z., Zhang, H., Zheng, S., Yang, X., Liu, C., Han, Q., Chen, Y., Li, Z., Zhang, X., Cao, L., Wang, Q., Cao, Y., Sun, X., Zhao, P.*, Li, X.*, Zheng, Q.*, Sheng, R.*HNF4alpha-CDKL3 axis restricts MASLD progression by targeting FoxO1 via noncanonical phosphorylation. Hepatology, 2024.
3. Zhao, P. #, Zhang, W.#, Wang, S.J .#, Yu, X.L., Tang, J., Huang, W., Li, Y., Cui, H.Y., Guo, Y.S., Tavernier, J., Zhang, S.H.*, Jiang, J.L.* and Chen, Z.N.* HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology, 54 (2011) 2012-2024.
4. Zhao, P. #, Damerow, M.S., Stern, P., Liu, A.H., Sweet-Cordero, A., Siziopikou, K., Neilson, J.R., Sharp, P.A.andCheng, C.* CD44 promotes Kras-dependent lung adenocarcinoma. Oncogene, 32 (2013) 5186-5190.
5. Zhang, YH., Sun, XT., Guo, RF., Feng, GY., Gao, HL., Zhong, ML., Tian, LW., Qiu, ZY., Cui, YW., Li, JY.*, Zhao P.* AbetaPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease. Matrix Biol, 2024;129:29-43.
6. Qiu, Y., Zhang, Y., Tian, L., Zou, Q., Zhao, P.* Identification of a comprehensive alternative splicing function during epithelial-mesenchymal transition. iScience, 2023;26:106517.
7. Zhang, YH. #, Zhao, P.# *, Gao, HL., Zhong, ML., Li, JY*. Screening Targets and Therapeutic Drugs for Alzheimer's Disease Based on Deep Learning Model and Molecular Docking. J Alzheimers Dis,2024;100:863-878.
8. Wang, Z., Zhang, Y.H., Guo, C., Gao, H.L., Zhong, M.L., Huang, T.T., Liu, N.N., Guo, R.F., Lan, T., Zhang, W., Wang, Z.Y.* and Zhao, P.* Tetrathiomolybdate Treatment Leads to the Suppression of Inflammatory Responses through the TRAF6/NFkappaB Pathway in LPS-Stimulated BV-2 Microglia. Frontiers in aging neuroscience, 10 (2018) 9.
9. Li, D.D., Zhang, W., Wang, Z.Y.* and Zhao, P.* Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies. Frontiers in aging neuroscience, 9 (2017) 300.
10. Zhao, P. #, Xu, Y., Wei, Y., Qiu, Q., Chew, T.L., Kang, Y.and Cheng, C.* The CD44s splice isoform is a central mediator for invadopodia activity. Journal of cell science, 129 (2016) 1355-1365.
11. Zhao, P. #, Zhang, W. #, Tang, J., Ma, X.K., Dai, J.Y., Li, Y., Jiang, J.L.*, Zhang, S.H.*andChen, Z.N.*Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer science, 101 (2010) 387-395.
12. Li, D.D., Zhang, Y.H., Zhang, W. *, Zhao, P. *, Meta-Analysis of Randomized Controlled Trials on the Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease, Frontiers in neuroscience, 13 (2019) 472.
13. Li, Y., Li, Z.X., Jin, T., Wang, Z.Y.* and Zhao, P.* Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases. Journal of Alzheimer's disease : JAD, 57 (2017) 395-409.
14. Zhang, W. #, Zhao, P.#, Xu, X.L., Cai, L., Song, Z.S., Cao, D.Y., Tao, K.S., Zhou, W.P., Chen, Z.N.*and Dou, K.F.*Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS One, 8 (2013) e67268.
部分合作论文：#共同第一作者，*通讯作者
1. Qiu, Y., Guo, D., Zhao, P., Zou, Q.* scMNMF: a novel method for single-cell multi-omics clustering based on matrix factorization. Briefings in bioinformatics 2024;25.
2. Qiu, Y., Yan, C., Zhao, P., Zou, Q.* SSNMDI: a novel joint learning model of semi-supervised non-negative matrix factorization and data imputation for clustering of single-cell RNA-seq data. Briefings in bioinformatics 2023.
3. Yang, Y., Tian, S., Qiu, Y., Zhao, P., Zou, Q.* MDICC: novel method for multi-omics data integration and cancer subtype identification, Briefings in bioinformatics, 23 (2022).
4. Zhang, H., Brown, R.L., Wei, Y., Zhao, P., Liu, S., Liu, X., Deng, Y., Hu, X., Zhang, J., Gao, X.D., Kang, Y., Mercurio, A.M., Goel, H.L., Cheng, C.* CD44 splice isoform switching determines breast cancer stem cell state, Genes & Development, 33 (2019) 166-179.
5. Qi, S., Su, L., Li, J., Zhao, P., Zhang, Q., Niu, X., Liu, J., Jia, G., Wei, X., Tavernier, J., Jiang, J., Chen, Z., Zhang, S.* YIPF2 is a novel Rab-GDF that enhances HCC malignant phenotypes by facilitating CD147 endocytic recycle, Cell death & disease, 10 (2019) 462.
联系方式
地址：辽宁省沈阳市浑南区创新路195号
邮编：110169
E-mail：zhaopu6687700@mail.neu.edu.cn；zhaopu6687700@163.com。